Nemifitide diTFA
CAS No. 204992-09-6
Nemifitide diTFA ( INN 00835 diTFA )
Catalog No. M29826 CAS No. 204992-09-6
Nemifitide (diTFA) is is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide (diTFA) is a peptide analog of melanocyte-inhibiting factor (MIF).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameNemifitide diTFA
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NoteResearch use only, not for human use.
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Brief DescriptionNemifitide (diTFA) is is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide (diTFA) is a peptide analog of melanocyte-inhibiting factor (MIF).
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DescriptionNemifitide (diTFA) is is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide (diTFA) is a peptide analog of melanocyte-inhibiting factor (MIF). (In Vitro):In-vitro studies indicate that both nemifitide and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin.(In Vivo):Nemifitide (0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect. Nemifitide (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
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SynonymsINN 00835 diTFA
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number204992-09-6
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Formula Weight922.8
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Molecular FormulaC37H45F7N10O10
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55(2-3):231-5.
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